Multiple pathways for sorting mitochondrial precursor proteins

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Multiple pathways for sorting mitochondrial precursor proteins.

Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal presequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the disc...

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Proteinaceous receptors for the import of mitochondrial precursor proteins.

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MOM19, an import receptor for mitochondrial precursor proteins.

We have identified a 19 kd protein of the mitochondrial outer membrane (MOM19). Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin, cytochrome c1, Fe/S protein, F0 ATPase subunit 9, and F1 ATPase subunit beta. Inhibition occurs at the level of high affinity binding of precursors t...

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Active unfolding of precursor proteins during mitochondrial protein import.

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2008

ISSN: 1469-221X,1469-3178

DOI: 10.1038/sj.embor.7401126